Abstract | BACKGROUND & AIMS: Tobacco smoking has a complex effect on intestinal inflammation, being protective in ulcerative colitis, whereas it aggravates Crohn's disease. The beneficial effect of smoking has been attributed to nicotine, but the mechanisms underlying the adverse effect are still under investigation. The aim of this study was to examine the effect of cigarette smoking on experimental colitis in rats and to investigate the underlying mechanism. METHODS: RESULTS: Exposure to cigarette smoke significantly increased macroscopic and histological damages as well as myeloperoxidase activity compared with sham-treated controls. Treatment with hexamethonium before smoking reversed the effect of the smoke on the colitis, improving all parameters. CONCLUSIONS: Exposure to cigarette smoke aggravates DNBS-induced colitis in the rat. This effect is reversed by hexamethonium, suggesting that a neural pathway is involved.
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Authors | F Galeazzi, P A Blennerhassett, B Qiu, P M O'Byrne, S M Collins |
Journal | Gastroenterology
(Gastroenterology)
Vol. 117
Issue 4
Pg. 877-83
(Oct 1999)
ISSN: 0016-5085 [Print] United States |
PMID | 10500070
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Ganglionic Blockers
- 2,4-dinitrofluorobenzene sulfonic acid
- Hexamethonium
- Nicotine
- Dinitrofluorobenzene
- Peroxidase
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Topics |
- Animals
- Colitis
(chemically induced, enzymology, pathology)
- Colon
(drug effects, enzymology, pathology)
- Dinitrofluorobenzene
(analogs & derivatives)
- Ganglionic Blockers
(pharmacology)
- Hexamethonium
(pharmacology)
- Male
- Nicotine
(pharmacology)
- Peroxidase
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Smoking
(adverse effects)
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