In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes.

Abstract

Natural killer (NK) receptor signaling can lead to reduced cytotoxicity by NK cells and cytolytic T lymphocytes (CTLs) in vitro. Whether T cells are inhibited in vivo remains unknown, since peptide antigen-specific CD8(+) T cells have so far not been found to express NK receptors in vivo. Here we demonstrate that melanoma patients may bear tumor-specific CTLs expressing NK receptors. The lysis of melanoma cells by patient-derived CTLs was inhibited by the NK receptor CD94/NKG2A. Thus, tumor-specific CTL activity may be decreased through NK receptor triggering in vivo.

• Authors: D E Speiser, M J Pittet, D Valmori, R Dunbar, D Rimoldi, D Liénard, H R MacDonald, J C Cerottini, V Cerundolo, P Romero
• Journal: The Journal of experimental medicine (J Exp Med) Vol. 190 Issue 6 Pg. 775-82 (Sep 20 1999) ISSN: 0022-1007 [Print] United States
• PMID: 10499916 (Publication Type: Journal Article)

Chemical References

• Antigens, CD
• Antigens, Neoplasm
• KLRC1 protein, human
• KLRD1 protein, human
• Lectins, C-Type
• Membrane Glycoproteins
• NK Cell Lectin-Like Receptor Subfamily C
• NK Cell Lectin-Like Receptor Subfamily D
• Receptors, Antigen, T-Cell
• Receptors, Immunologic
• Receptors, Natural Killer Cell

Topics

• Antigens, CD (immunology)
• Antigens, Neoplasm (immunology)
• Cytotoxicity, Immunologic
• Flow Cytometry
• Humans
• Killer Cells, Natural (immunology)
• Lectins, C-Type
• Melanoma (immunology)
• Membrane Glycoproteins (immunology)
• NK Cell Lectin-Like Receptor Subfamily C
• NK Cell Lectin-Like Receptor Subfamily D
• Receptors, Antigen, T-Cell (immunology)
• Receptors, Immunologic (immunology)
• Receptors, Natural Killer Cell
• T-Lymphocytes, Cytotoxic (immunology)