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Lithium and clonazepam treatment of two cases with cluster headache.

Abstract
Patients with cluster headache are often treated with lithium. However, there are some patients who can not be fully treated with lithium alone. Two patients with cluster headache were treated with clonazepam, one of the most potent benzodiazepines. Lithium prolonged the period of remission, and the addition of clonazepam further prolonged it in case 1. Treatment with clonazepam reduced the symptoms in case 2, and when combined with lithium, the disorder went into remission after 6 months. These findings suggest that the combination of lithium and clonazepam may be effective in patients with cluster headache.
AuthorsM Takebayashi, T Fujikawa, A Kagaya, J Horiguchi, S Yamawaki
JournalPsychiatry and clinical neurosciences (Psychiatry Clin Neurosci) Vol. 53 Issue 4 Pg. 535-7 (Aug 1999) ISSN: 1323-1316 [Print] Australia
PMID10498239 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anticonvulsants
  • Antimanic Agents
  • Lithium Carbonate
  • Clonazepam
Topics
  • Adult
  • Anticonvulsants (administration & dosage)
  • Antimanic Agents (administration & dosage)
  • Clonazepam (administration & dosage)
  • Cluster Headache (drug therapy)
  • Drug Therapy, Combination
  • Humans
  • Lithium Carbonate (administration & dosage)
  • Male
  • Time Factors
  • Treatment Outcome

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