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Hepatic production of apolar aldehydes in rats with carbon tetrachloride-induced cirrhosis.

Abstract
The aim of this study was to identify apolar aldehydes in liver homogenates from rats with CCl4-induced cirrhosis and, as a corollary, the antioxidant effect of zinc administration. The study was performed in five control rats and in ten cirrhotic rats which were further sub-divided into two groups to receive either a standard diet or one supplemented with zinc. The percentage of hepatic fibrosis, plasma malondialdehyde concentration and alanine aminotransferase activity were measured as well as the following aldehydes: hexanal, octanal, decanal, 2-hexenal, 2-octenal, 2-nonenal, 2,4-heptadienal and 2,4-decadienal. Of the 10 cirrhotic rats, 4 had elevated concentrations of the highly toxic 2,4-dialkenals which coincided with a higher percentage of fibrosis and plasma alanine aminotransferase activity. These aldehydes were not observed in the control group. Zinc administration was associated with a reduction of the hepatic malondialdehyde concentration and an amelioration on the degree of hepatic injury. In conclusion, this study demonstrates the presence of the highly toxic 2,4-dialkenals in hepatic tissue of rats whith CCl4-induced cirrhosis. Results obtained would suggest that these particular aldehydes may be related to the severity of the hepatic injury.
AuthorsN Ferré, J Girona, M Cabré, J Joven, A LaVille, L Masana, J L Paternáin, J Camps
JournalMolecular and cellular biochemistry (Mol Cell Biochem) Vol. 198 Issue 1-2 Pg. 57-60 (Aug 1999) ISSN: 0300-8177 [Print] Netherlands
PMID10497878 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Aldehydes
  • Antioxidants
  • Carbon Tetrachloride
  • Zinc
Topics
  • Aldehydes (metabolism)
  • Animals
  • Antioxidants (pharmacology)
  • Carbon Tetrachloride (toxicity)
  • Liver (drug effects, metabolism)
  • Liver Cirrhosis, Experimental (chemically induced, metabolism, prevention & control)
  • Male
  • Rats
  • Rats, Wistar
  • Zinc (pharmacology)

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