Role of gamma interferon in controlling murine chlamydial genital tract infection.

Earlier investigations have not shown an important role for gamma interferon (IFN-gamma) in the early clearance of chlamydial infection from the murine female genital tract. In a model using a human genital isolate of Chlamydia trachomatis in IFN-gamma and IFN-gamma receptor knockout mice, we were able to demonstrate a major role for IFN-gamma in mediating control of infection throughout the course of infection.
AuthorsJ I Ito, J M Lyons
JournalInfection and immunity (Infect Immun) Vol. 67 Issue 10 Pg. 5518-21 (Oct 1999) ISSN: 0019-9567 [Print] UNITED STATES
PMID10496942 (Publication Type: Journal Article)
Chemical References
  • Receptors, Interferon
  • interferon gamma receptor
  • Interferon-gamma
  • Animals
  • Chlamydia Infections (immunology)
  • Chlamydia trachomatis
  • Female
  • Genital Diseases, Female (immunology)
  • Humans
  • Interferon-gamma (physiology)
  • Mice
  • Mice, Knockout
  • Receptors, Interferon (physiology)

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