MRI detection of new hemorrhages: potential marker of progression in cerebral amyloid angiopathy.

Abstract

The authors used serial gradient-echo MRIs to detect new small hemorrhages in patients with previous lobar hemorrhage. Of 24 lobar hemorrhage patients (17 diagnosed with probable and 7 with possible amyloid angiopathy) who prospectively underwent repeat MRI 1.5 years after initial study, 9 (38%) demonstrated additional hemorrhages at follow-up. Interrater agreement was high. New hemorrhages were more frequent in patients with probable amyloid angiopathy (8 of 17, 47%) with more hemorrhages at baseline (p < 0.01). These results suggest a role for gradient-echo MRI in assessing disease progression in amyloid angiopathy.

• Authors: S M Greenberg, H C O'Donnell, P W Schaefer, E Kraft
• Journal: Neurology (Neurology) Vol. 53 Issue 5 Pg. 1135-8 (Sep 22 1999) ISSN: 0028-3878 [Print] United States
• PMID: 10496283 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Topics

• Aged
• Aged, 80 and over
• Brain (pathology)
• Cerebral Amyloid Angiopathy (pathology)
• Cerebral Hemorrhage (pathology)
• Female
• Humans
• Magnetic Resonance Imaging
• Male
• Prospective Studies