HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Contact immunotherapy with squaric acid dibutylester for the treatment of recalcitrant warts.

AbstractBACKGROUND:
Contact immunotherapy has been shown to be effective for warts. Two previous studies on the use of squaric acid dibutylester (SADBE) for warts have reported widely divergent cure rates (10% and 60%).
OBJECTIVE:
Our purpose was to determine the efficacy of SADBE in the treatment of recalcitrant warts.
METHODS:
We treated 29 patients with SADBE for warts that were resistant to other therapies. The patient population had warts for a mean duration of 2.1 years. Patients were sensitized with 1% or 2% SADBE in acetone under occlusion, then treated with 0.5% to 5% SADBE applied to their warts every 2 to 4 weeks in the office.
RESULTS:
Clearing of all warts was seen in 20 of 29 patients (69%), improvement in 3 patients (10%), and no change in 6 patients (21%). For the cured patients, mean duration of treatment was 4.2 months (range, 1 to 12 months) and mean number of treatments was 5.7 (range, 2 to 15). Adverse effects included acute contact dermatitis with 6 patients experiencing blisters and one experiencing hypopigmentation.
CONCLUSION:
SADBE treatment is worth considering in patients with recalcitrant warts, especially in those who tolerate painful procedures poorly.
AuthorsA N Lee, S B Mallory
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 41 Issue 4 Pg. 595-9 (Oct 1999) ISSN: 0190-9622 [Print] United States
PMID10495383 (Publication Type: Journal Article)
Chemical References
  • Allergens
  • Cyclobutanes
  • squaric acid dibutyl ester
Topics
  • Adolescent
  • Adult
  • Allergens (adverse effects, immunology, therapeutic use)
  • Child
  • Child, Preschool
  • Cyclobutanes (adverse effects, immunology, therapeutic use)
  • Female
  • Humans
  • Immunotherapy
  • Infant
  • Male
  • Recurrence
  • Warts (therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: