The 25-year experience with the underbandage treatment of soft tissue purulent
wounds of various location and genesis with modern
ointments with
polyethylene glycol as the basis was analyzed. Levocin, levomecole, dioxycole, 5-percent dioxydinic, 1-percent iodopyronic, 0.5-percent
quinifuryl and furagel
ointments proved to preserve their high activity against aerobic grampositive and gramnegative flora. 10-percent
mafenide acetate ointment had a high selective effect on Pseudomonas aeruginosa. The new
ointments nitacid and streptonitole containing
nitazole and white streptocide were highly active against both aerobic and anaerobic
infections. The use of the
ointments with the
polyethylene glycol as the basis made it possible to decrease 2 times the period of the patient hospitalization in surgical units and to shorten the terms of the systemic antibacterial
therapy. The marked
therapeutic effect of such
ointments due to their high dehydrating capacity and broad antibacterial spectrum enabled to consider them as the drugs of choice in the local treatment of purulent
wounds during the 1st phase of the
wound process, trophic and decubic
ulcers, infected
burns, diabetic and atherosclerotic
gangrene,
furuncles,
carbuncles,
mastitis, etc. The
ointments in the water soluble vehicle can be as well used with success for the prophylactic treatment of infected
wounds after the
suture. The multitarget effect of the
ointments in the water soluble vehicle and their ability to prevent severe purulent complications permitted to consider them as the 1st order drugs in cases of emergency.