[Assessment of the mutagenic activity of aversectin C].

Abstract

Aversectin C was evaluated for mutagenic activity in the Ames test with Salmonella typhimurium TA 97, TA 98 and TA 100, in the dominant lethal assay on uninbred albino rats in a dose of 2.25 mg/kg body weight (1/40 of the LD50) and in the metaphase test on F1CBAxC57BI/6 mice in a dose of 8.2 mg/kg body weight (1/5 of the LD50). The agent showed no mutagenic activity in any of the tests. The anaphase test on F1CBAxC57BI/6 mice revealed no antimitotic activity of aversectin C.

• Authors: T S Novik, R V Baru, V A Riabova, V A Piatova, V A Driniaev, S I Chukina, E B Krugliak, V A Mosin
• Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 44 Issue 7 Pg. 16-20 ( 1999) ISSN: 0235-2990 [Print] Russia (Federation)
• Vernacular Title: Otsenka mutagennoĭ aktivnosti aversektina C.
• PMID: 10494378 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Mutagens
• Ivermectin
• avermectin

Topics

• Anaphase (drug effects)
• Animals
• Anti-Bacterial Agents (toxicity)
• Bone Marrow Cells (drug effects)
• Ivermectin (analogs & derivatives, toxicity)
• Lethal Dose 50
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Inbred CBA
• Mitosis (drug effects)
• Mutagenicity Tests
• Mutagens (toxicity)
• Rats
• Salmonella typhimurium (genetics)