HLA-DMA and HLA-DMB genotyping in patients with systemic lupus erythematosus.

Abstract

UNLABELLED:

OBJECTIVE. To investigate the relation of HLA-DMA and DMB alleles to the development of systemic lupus erythematosus (SLE).

METHODS:

We studied HLA-DMA and DMB alleles in 108 patients with SLE and 138 healthy controls using the amplification created restriction site method.

RESULTS:

The phenotypic frequency of HLA-DMA*0104 was significantly higher in patients with SLE than in healthy controls. The HLA-DMA and DMB alleles were not related to clinical manifestations and various laboratory tests in patients with SLE.

CONCLUSION:

HLA-DMA*0104 may be associated with the susceptibility of SLE.

• Authors: J H Yen, C J Chen, W C Tsai, J J Tsai, T T Ou, H W Liu
• Journal: The Journal of rheumatology (J Rheumatol) Vol. 26 Issue 9 Pg. 1930-3 (Sep 1999) ISSN: 0315-162X [Print] Canada
• PMID: 10493671 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Genetic Markers
• H2-M antigens
• HLA-D Antigens
• HLA-DM antigens
• Histocompatibility Antigens Class II

Topics

• Adolescent
• Adult
• Alleles
• Female
• Gene Frequency
• Genetic Markers
• Genotype
• HLA-D Antigens (analysis)
• Histocompatibility Antigens Class II
• Humans
• Lupus Erythematosus, Systemic (diagnosis, genetics)
• Male
• Middle Aged
• Sensitivity and Specificity
• Taiwan