Amphicrine tumor.

Abstract

The term amphicrine refers to cells, and tumors, which show both exocrine and endocrine features. Author s aim was to analyse the characteristics of these neoplasms. 40 suspicious cases were reviewed. Mucin-stains (PAS, diastase-PAS, Stains-all, Alcian-blue), immunohistochemistry (antibodies against Neuron-Specific Enolase (NSE), and Chromogranin A (CGA), and electronmicroscopic studies were performed to demonstrate exocrine and/or endocrine features of the tumor cells. By means of these methods, 16 cases turned out to be amphicrine tumors. Among them, there were 4 sinonasal, 1 bronchial, 1 mediastinal, 8 gastrointestinal and 2 suprarenal gland neoplasms. In connection to the subject, a brief review is given of amphicrine tumor, regarding its etiological and pathological aspects. These tumors form a distinct clinicopathological entity and should be separated from both neuroendocrine tumors and adenocarcinomas.

• Authors: L Mándoky
• Journal: Pathology oncology research : POR (Pathol Oncol Res) Vol. 5 Issue 3 Pg. 239-44 ( 1999) ISSN: 1219-4956 [Print] Switzerland
• PMID: 10491026 (Publication Type: Case Reports, Journal Article)

Chemical References

• Mucins

Topics

• Adenocarcinoma (diagnosis, pathology, ultrastructure)
• Adrenal Gland Neoplasms (diagnosis, pathology, ultrastructure)
• Adult
• Aged
• Bronchial Neoplasms (pathology, ultrastructure)
• Carcinoid Tumor (diagnosis, pathology, ultrastructure)
• Female
• Gastrointestinal Neoplasms (pathology, ultrastructure)
• Humans
• Kidney Neoplasms (pathology, ultrastructure)
• Male
• Mediastinal Neoplasms (pathology, ultrastructure)
• Microscopy, Electron
• Middle Aged
• Mucins (analysis)
• Neoplasms, Complex and Mixed (diagnosis, pathology, ultrastructure)
• Paranasal Sinus Neoplasms (pathology, ultrastructure)