Abstract | BACKGROUND/AIMS: The prevalence and risks factors of bacteriuria in cirrhotics have not been assessed by case-control study, and there are conflicting data concerning the role of liver failure and of ascites. The aims of this study were: i) to evaluate the prevalence of bacteriuria in cirrhotics, ii) to search for associated factors, iii) to evaluate the role of bladder post-void residual volume, and iv) to test the sensitivity of isolated bacteria to norfloxacin. METHODS: The prevalence and risk factors of bacteriuria on admission were determined by a multicenter prospective case-control study. RESULTS: Two hundred and forty-four cirrhotic patients and 240 controls were studied. Bacteriuria was present in 38 patients (15.6%; IC 5%: 11%-20%) and 18 controls (7.5%; IC 5%: 4.2%-11%; p<0.001). By univariate analysis, female sex and ongoing diuretic treatment were associated with bacteriuria (p<0.0001 and p<0.04, respectively). Pugh's grade, ascites and bladder residual volume were not associated with bacteriuria. By multivariate analysis, female sex (p<0.0001) and Child-Pugh score (p<0.03) were predictors of bacteriuria. Sensitivity of bacteria to norfloxacin was observed in 94.7%; sterile urine cultures were noted in 95.2% of patients treated with this antibiotic. CONCLUSION:
Bacteriuria is twice as frequent in cirrhotic patients as in matched controls, and there is a trend to association with female sex and liver insufficiency.
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Authors | J F Cadranel, J Denis, A Pauwels, J C Barbare, C Eugène, V di Martino, E Poquet, A Medini, P Coutarel, J P Latrive, P Lemaître, B Devergie |
Journal | Journal of hepatology
(J Hepatol)
Vol. 31
Issue 3
Pg. 464-8
(Sep 1999)
ISSN: 0168-8278 [Print] Netherlands |
PMID | 10488705
(Publication Type: Journal Article, Multicenter Study)
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Chemical References |
- Anti-Infective Agents
- Norfloxacin
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Topics |
- Anti-Infective Agents
(therapeutic use)
- Case-Control Studies
- Female
- Humans
- Liver Cirrhosis
(microbiology, urine)
- Male
- Microbial Sensitivity Tests
- Middle Aged
- Norfloxacin
(therapeutic use)
- Prevalence
- Prospective Studies
- Risk Factors
- Urinary Retention
(microbiology)
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