[Organ donation by living donors in isolated pancreas and simultaneous pancreas-kidney transplantation].

We studied retrospectively 106 pancreas transplants from living donors. Of these, 83 were solitary pancreas transplants, done between June 1979 and December 1997 (51 pancreas transplants alone for non-uremic recipients as well as 32 pancreas-after-kidney transplants for previously uremic recipients with a functioning kidney graft), and 23 were simultaneous pancreas-kidney transplants (SPK), done between March 1994 and December 1997. In all, 105 (99%) donors were genetically related to the recipients. Perioperative donor mortality was 0%. Donor complications included 9 splenectomies as well as 4 operatively drained and 7 percutaneously managed peripancreatic fluid collections. We noted hyperglycemia in 3 (3%) donors (all among the initial cases in this series). The 1-year survival rate was 50% for solitary pancreas recipients and 78% (pancreas) and 100% (kidney) for SPK recipients. Of the 5 pancreas graft losses which occurred after SPK, 3 were due to thrombosis, 1 to pancreatitis and infection, and 1 to chronic rejection. Currently, all kidney grafts and 18 pancreas grafts are functioning in these 23 dual organ recipients (with 0% recipient mortality). Living donor pancreas and SPK grafting is associated with low donor morbidity and good graft outcome. With stringent donor criteria and appropriate counseling of the prospective donor/recipient pairs, living donor pancreas transplants may become a more widely applied therapeutic alternative for selected non-uremic and uremic patients with Type I diabetes.
AuthorsC Troppmann, A C Grüssner, D E Sutherland, R W Grüssner
JournalZentralblatt für Chirurgie (Zentralbl Chir) Vol. 124 Issue 8 Pg. 734-8 ( 1999) ISSN: 0044-409X [Print] GERMANY
Vernacular TitleDie Lebend-Organspende in der isolierten Pankreas- und simultanen Pankreas-Nieren-Transplantation.
PMID10488545 (Publication Type: English Abstract, Journal Article)
  • Diabetes Mellitus, Type 2 (mortality, surgery)
  • Diabetic Nephropathies (mortality, surgery)
  • Graft Rejection (etiology, mortality)
  • Humans
  • Kidney Transplantation
  • Living Donors
  • Nephrectomy
  • Pancreas Transplantation
  • Pancreatectomy
  • Postoperative Complications (etiology, mortality)
  • Reoperation
  • Retrospective Studies
  • Risk Factors
  • Survival Rate
  • Uremia (mortality, surgery)

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