Abstract | BACKGROUND: Saliva protects the oral mucosa, inhibiting microbial overgrowth. Hyposalivation, therefore, induces multiple oral disorders, although treatment of hyposalivation is very difficult. METHODS: RESULTS: Two weeks after administration of AT (6 tablets per day), both nonstimulated salivary flow rate (SFR) and stimulated SFR increased in a statistically significantly manner from 0.76 +/- 0.41 and 5.18 +/- 3.02 to 1.54 +/- 1.33 (P<0.05) and 9.07 +/- 4.10 mL/10 min (P<0.05), respectively. Of the three groups, the drug group showed the largest increases in both SFRs, from 0.90 +/- 0.54 and 6.29 +/- 4.12 to 1.69 +/- 1.65 and 12.09 +/- 5.10 mL/10 min (P<0.05 and P<0.02, respectively). Patients in the control group had almost constant SFRs. After AT administration, the salivary viscosity was, however, mildly decreased and concentrations of secretory-immunoglobulin A, lactoferrin, potassium, and chloride in nonstimulated saliva were almost constant. Corresponding with the increase of salivation, oral discomfort and inflammation were improved or resolved in 41 patients of the AT group within about 4 weeks, whereas improvement was observed in only nine patients of the control group. CONCLUSIONS: These results indicate that AT sufficiently stimulates salivation and improves xerostomia.
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Authors | T Hamada, T Nakane, T Kimura, K Arisawa, K Yoneda, T Yamamoto, T Osaki |
Journal | The American journal of the medical sciences
(Am J Med Sci)
Vol. 318
Issue 3
Pg. 146-51
(Sep 1999)
ISSN: 0002-9629 [Print] United States |
PMID | 10487404
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholagogues and Choleretics
- Saliva, Artificial
- Anethole Trithione
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Anethole Trithione
(therapeutic use)
- Cholagogues and Choleretics
(therapeutic use)
- Female
- Humans
- Male
- Middle Aged
- Saliva
(metabolism)
- Saliva, Artificial
(therapeutic use)
- Salivation
(drug effects)
- Treatment Outcome
- Viscosity
- Xerostomia
(drug therapy, etiology, metabolism, physiopathology)
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