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Tiagabine-induced absence status in idiopathic generalized epilepsy.

Abstract
Several medications such as baclofen, amitriptyline and even antiepileptic drugs such as carbamazepine or vigabatrin are known to induce absence status epilepticus in patients with generalized epilepsies. Tiagabine (TGB) is effective in patients with focal epilepsies. However, TGB has also been reported to induce non-convulsive status epilepticus in several patients with focal epilepsies and in one patient with juvenile myoclonic epilepsy. In animal models of generalized epilepsy, TGB induces absence status with 3-5 Hz spike-wave complexes. We describe a 32-year-old patient with absence epilepsy and primary generalized tonic-clonic seizures since 11 years of age, who developed her first absence status epilepticus while treated with 45 mg of TGB daily. Administration of lorazepam and immediate reduction in TGB dosage was followed by complete clinical and electroencephalographic remission. This case demonstrates that TGB can induce typical absence status epilepticus in a patient with primary generalized epilepsy.
AuthorsS Knake, H M Hamer, U Schomburg, W H Oertel, F Rosenow
JournalSeizure (Seizure) Vol. 8 Issue 5 Pg. 314-7 (Aug 1999) ISSN: 1059-1311 [Print] England
PMID10486298 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright 1999 BEA Trading Ltd.
Chemical References
  • Anticonvulsants
  • Nipecotic Acids
  • Tiagabine
Topics
  • Adult
  • Anticonvulsants (adverse effects)
  • Epilepsy, Absence (chemically induced, diagnosis)
  • Epilepsy, Generalized (drug therapy)
  • Female
  • Humans
  • Nipecotic Acids (adverse effects)
  • Status Epilepticus (chemically induced)
  • Tiagabine

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