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Expression and function of CD30 on T lymphocytes.

Abstract
T cell receptor, accessory molecules, cytokines are important regulatory factors that determine the development and function of T lymphocytes. Among them are also molecules belonging to superfamily of tumor necrosis factor receptor (TNFR) which beside CD30 include CD27, CD40, TNFR-I and -II, Fas (CD95), OX40, 4-1BB (CDw137), nerve growth factor receptor, lymphotoxin-beta receptor, Apo3/DR3/Ws1-1/lymphocyte associated receptor of death, DR4, DR5/TNF-related apoptosis-inducing ligand, osteoprotegerin, and TNFR-related 2. CD30 recognized originally on Reed-Sternberg cells of Hodgkin's lymphoma became of interest in studies of Th1 and Th2 cell differentiation. This paper shows recent findings regarding CD30 expression and its pleiotropic role in T cell function. It provides information about controversial role of CD30 as Th2 cell differentiation marker and gives concise insight into the function of this receptor as a signal transducing molecule.
AuthorsM Tarkowski
JournalArchivum immunologiae et therapiae experimentalis (Arch Immunol Ther Exp (Warsz)) Vol. 47 Issue 4 Pg. 217-21 ( 1999) ISSN: 0004-069X [Print] Switzerland
PMID10483869 (Publication Type: Journal Article, Review)
Chemical References
  • Ki-1 Antigen
  • Receptors, Tumor Necrosis Factor
Topics
  • Animals
  • Humans
  • Ki-1 Antigen (biosynthesis, physiology)
  • Receptors, Tumor Necrosis Factor (biosynthesis, physiology)
  • T-Lymphocytes (immunology, metabolism)

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