Abstract |
T cell receptor, accessory molecules, cytokines are important regulatory factors that determine the development and function of T lymphocytes. Among them are also molecules belonging to superfamily of tumor necrosis factor receptor (TNFR) which beside CD30 include CD27, CD40, TNFR-I and -II, Fas (CD95), OX40, 4-1BB (CDw137), nerve growth factor receptor, lymphotoxin-beta receptor, Apo3/DR3/Ws1-1/lymphocyte associated receptor of death, DR4, DR5/ TNF-related apoptosis-inducing ligand, osteoprotegerin, and TNFR-related 2. CD30 recognized originally on Reed-Sternberg cells of Hodgkin's lymphoma became of interest in studies of Th1 and Th2 cell differentiation. This paper shows recent findings regarding CD30 expression and its pleiotropic role in T cell function. It provides information about controversial role of CD30 as Th2 cell differentiation marker and gives concise insight into the function of this receptor as a signal transducing molecule.
|
Authors | M Tarkowski |
Journal | Archivum immunologiae et therapiae experimentalis
(Arch Immunol Ther Exp (Warsz))
Vol. 47
Issue 4
Pg. 217-21
( 1999)
ISSN: 0004-069X [Print] Switzerland |
PMID | 10483869
(Publication Type: Journal Article, Review)
|
Chemical References |
- Ki-1 Antigen
- Receptors, Tumor Necrosis Factor
|
Topics |
- Animals
- Humans
- Ki-1 Antigen
(biosynthesis, physiology)
- Receptors, Tumor Necrosis Factor
(biosynthesis, physiology)
- T-Lymphocytes
(immunology, metabolism)
|