[Anti-thyroid peroxidase antibody].

Abstract

Anti-thyroid peroxidase antibody(TPOAb) in patients with autoimmune thyroid diseases was identified with anti-microsomal antibody. Highly sensitive assays of TPOAb using radioimmunoassays and enzyme immunoassays have been developed following a hemagglutination assay technique. TPOAb is present in the serum of almost all patients with Hashimoto's thyroiditis, in more than 70% of those with Graves' disease, and, to a variable degree, in patients with nonthyroid autoimmune diseases and some normal subjects. There is a good correlation between the degree of lymphocytic infiltration of the thyroid gland and the titer of TPOAb. Postpartum thyroiditis, usually a transient disorder, occurs with high frequency in women who have TPOAb. TPOAb, in addition to anti-thyroglobulin antibody, was a clinically useful marker for defining autoimmune thyroid diseases and for detecting an underlying autoimmune process in the thyroid, however, its biological importance remains to be clarified at the present time.

• Authors: T Inukai, Y Takemura
• Journal: Nihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 57 Issue 8 Pg. 1819-23 (Aug 1999) ISSN: 0047-1852 [Print] Japan
• PMID: 10483258 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Autoantibodies
• Iodide Peroxidase

Topics

• Autoantibodies (blood)
• Autoimmune Diseases (diagnosis)
• Female
• Humans
• Immunoenzyme Techniques
• Iodide Peroxidase (immunology)
• Puerperal Disorders (diagnosis)
• Radioimmunoassay
• Thyroid Diseases (diagnosis)