Abstract | OBJECTIVES: METHODS: Frozen sections of tissue samples obtained from normal human keratinized (16 subjects) and non-keratinized (three subjects) oral mucosa, oral leukopakias with dysplasia (19 subjects), reticular type lichen planus (nine subjects), or oral mucosal SCC (23 subjects) were stained immunohistochemically with antibodies against alpha9 integrin and TN. RESULTS: In contrast to its most prominent localization at the cell membranes of the basal epithelial cells in the normal mucosa, alpha9 integrin was localized in a more diffuse pattern with focal loss of expression at the epithelial cell membranes in leukoplakic dysplasia, lichen planus, and SCC. In some areas of SCC, alpha9 integrin localized throughout all cell layers of the tumor epithelium. In most areas, alpha9 integrin colocalized with TN but in heavily inflamed areas there was focal loss of TN and alpha9 integrin at the basement membrane zone. CONCLUSIONS:
|
Authors | L Häkkinen, T Kainulainen, T Salo, R Grenman, H Larjava |
Journal | Oral diseases
(Oral Dis)
Vol. 5
Issue 3
Pg. 210-7
(Jul 1999)
ISSN: 1354-523X [Print] Denmark |
PMID | 10483066
(Publication Type: Journal Article)
|
Chemical References |
- Integrin alpha Chains
- Integrins
- Neoplasm Proteins
- Tenascin
- integrin alpha9
|
Topics |
- Carcinoma, Squamous Cell
(metabolism)
- Humans
- Immunohistochemistry
- Integrin alpha Chains
- Integrins
(analysis, metabolism)
- Leukoplakia, Oral
(metabolism)
- Lichen Planus, Oral
(metabolism)
- Mouth Mucosa
(metabolism)
- Mouth Neoplasms
(metabolism)
- Neoplasm Proteins
(analysis, metabolism)
- Tenascin
(analysis, metabolism)
|