Abstract |
This study was carried out to clarify the frequency of detection of antibody activity to ribosomal protein S10 (anti-S10) in patients with systemic lupus erythematosus (SLE) with anti-Sm antibodies (anti-Sm), and clinical differences between anti-Sm-positive SLE patients with and without anti-S10. Twenty-seven of 31 serum samples containing anti-Sm reacted with ribosomal protein S10 along with Sm core proteins B/B' and D (87.1%). Four serum samples containing anti-Sm against only B/B' but not D did not react with S10 (12.9%). Patients who had both anti-Sm and anti-S10 showed lower serum complements levels, high frequency of skin lesion and anti-double-stranded DNA antibody. Many anti-Sm antibodies may recognize B/B', D, and S10 simultaneously, and such antibodies may appear in active disease.
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Authors | H Hasegawa, T Uchiumi, T Sato, Y Ofuchi, S Murakami, S Honda, S Hirose, S Ito, M Nakano, M Arakawa, F Gejyo |
Journal | Lupus
(Lupus)
Vol. 8
Issue 6
Pg. 439-43
( 1999)
ISSN: 0961-2033 [Print] England |
PMID | 10483011
(Publication Type: Journal Article)
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Chemical References |
- Autoantibodies
- Autoantigens
- Ribonucleoproteins, Small Nuclear
- Ribosomal Proteins
- ribosomal protein S10
- snRNP Core Proteins
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Topics |
- Antibody Specificity
- Autoantibodies
(blood, immunology)
- Autoantigens
(immunology)
- Cross Reactions
- Humans
- Lupus Erythematosus, Systemic
(blood, immunology)
- Ribonucleoproteins, Small Nuclear
(immunology)
- Ribosomal Proteins
(immunology)
- snRNP Core Proteins
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