High frequency of antibody activity against ribosomal protein S10 in anti-Sm sera from patients with systemic lupus erythematosus.

Abstract

This study was carried out to clarify the frequency of detection of antibody activity to ribosomal protein S10 (anti-S10) in patients with systemic lupus erythematosus (SLE) with anti-Sm antibodies (anti-Sm), and clinical differences between anti-Sm-positive SLE patients with and without anti-S10. Twenty-seven of 31 serum samples containing anti-Sm reacted with ribosomal protein S10 along with Sm core proteins B/B' and D (87.1%). Four serum samples containing anti-Sm against only B/B' but not D did not react with S10 (12.9%). Patients who had both anti-Sm and anti-S10 showed lower serum complements levels, high frequency of skin lesion and anti-double-stranded DNA antibody. Many anti-Sm antibodies may recognize B/B', D, and S10 simultaneously, and such antibodies may appear in active disease.

• Authors: H Hasegawa, T Uchiumi, T Sato, Y Ofuchi, S Murakami, S Honda, S Hirose, S Ito, M Nakano, M Arakawa, F Gejyo
• Journal: Lupus (Lupus) Vol. 8 Issue 6 Pg. 439-43 ( 1999) ISSN: 0961-2033 [Print] England
• PMID: 10483011 (Publication Type: Journal Article)

Chemical References

• Autoantibodies
• Autoantigens
• Ribonucleoproteins, Small Nuclear
• Ribosomal Proteins
• ribosomal protein S10
• snRNP Core Proteins

Topics

• Antibody Specificity
• Autoantibodies (blood, immunology)
• Autoantigens (immunology)
• Cross Reactions
• Humans
• Lupus Erythematosus, Systemic (blood, immunology)
• Ribonucleoproteins, Small Nuclear (immunology)
• Ribosomal Proteins (immunology)
• snRNP Core Proteins