[Metabolism of androgens in various histological variants of bone tumors].

Abstract

The role of androgens in human normal and neoplastic bone tissues is still unclear. The paper presents data on metabolism of androgens in homogenates of malignant (osteosarcoma, chondrosarcoma, Ewing and giant cell) and benign primary tumors from 46 male and female patients aged 14-58 years. Using two substrates (testosterone and 5 alpha-dihydrotestosterone) for the first time are shown activities of main enzymes of androgen metabolism in all tumor types. 5 alpha-reductase activity was similar in all tumors, 3 alpha-hydroxysteroid dehydrogenase activity was the highest while that of 17 beta-hydroxysteroid dehydrogenase was the lowest. Unknown metabolite(s) of 5 alpha-dehydrotestosterone was discovered which may be hydroxy-metabolites of 5 alpha-androstane-3 beta, 17 beta-diol. A principal scheme of androgen metabolism in human neoplastic tissue is proposed.

• Authors: N E Kushlinskiĭ, V G Degtiar', T V Babkina, Iu N Solov'ev, N N Trapeznikov
• Journal: Arkhiv patologii (Arkh Patol) 1999 May-Jun Vol. 61 Issue 3 Pg. 25-30 ISSN: 0004-1955 [Print] Russia (Federation)
• Vernacular Title: Osobennosti metabolizma androgenov v razlichnykh gistologicheskikh variantakh opukholeĭ kosteĭ.
• PMID: 10476344 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Androgens
• Dihydrotestosterone
• Testosterone
• 17-Hydroxysteroid Dehydrogenases
• 3-Hydroxysteroid Dehydrogenases
• 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)
• 3 (or 17)-beta-hydroxysteroid dehydrogenase
• 3-Oxo-5-alpha-Steroid 4-Dehydrogenase

Topics

• 17-Hydroxysteroid Dehydrogenases (metabolism)
• 3-Hydroxysteroid Dehydrogenases (metabolism)
• 3-Oxo-5-alpha-Steroid 4-Dehydrogenase (metabolism)
• 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)
• Adolescent
• Adult
• Androgens (metabolism)
• Bone Neoplasms (metabolism, pathology)
• Dihydrotestosterone (metabolism)
• Female
• Humans
• Male
• Middle Aged
• Testosterone (metabolism)