Abstract | AIM: SUBJECTS AND METHODS: It was a placebo-controlled double-blind 6-way crossover study design with 12 human volunteers. Acute pain was generated by electrical tooth pulp stimulation. Treatment effects were determined by recording somatosensory-evoked potentials and by subjective pain rating. RESULTS: The tilidine/ naloxone combination clearly was the most potent medication in this study, followed by bromfenac 75 mg, which produced an early pain relief. Tramadol produced poor analgesia, as did bromfenac 25 and 50 mg. There was no dose-response relationship for bromfenac. Control of plasma levels revealed pronounced interindividual differences in peak plasma concentrations for bromfenac, but not for tramadol. Tilidine/ naloxone exerted adverse effects in 9, tramadol in 3 volunteers. Under medication with 25 and 50 mg bromfenac, respectively, only one subject reported adverse effects. No adverse effects were experienced with 75 mg bromfenac or placebo. CONCLUSION: The results support previous conclusions about the analgesic efficacy of tilidine/ naloxone and tramadol in experimental pain. Moreover, the findings suggest that 75 mg bromfenac might be suitable for fast but short relief of pain of non-inflammatory genesis.
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Authors | P Högger, P Rohdewald |
Journal | International journal of clinical pharmacology and therapeutics
(Int J Clin Pharmacol Ther)
Vol. 37
Issue 8
Pg. 377-85
(Aug 1999)
ISSN: 0946-1965 [Print] Germany |
PMID | 10475140
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics
- Benzophenones
- Bromobenzenes
- Drug Combinations
- Valoron N
- Naloxone
- Tramadol
- bromfenac
- Tilidine
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Topics |
- Adult
- Analgesics
(adverse effects, blood, pharmacokinetics, therapeutic use)
- Area Under Curve
- Benzophenones
(adverse effects, blood, pharmacokinetics, therapeutic use)
- Bromobenzenes
(adverse effects, blood, pharmacokinetics, therapeutic use)
- Cross-Over Studies
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Combinations
- Drug Therapy, Combination
- Evoked Potentials, Somatosensory
(drug effects)
- Female
- Humans
- Male
- Naloxone
(adverse effects, blood, pharmacokinetics, therapeutic use)
- Pain
(blood, drug therapy, etiology, metabolism)
- Tilidine
(adverse effects, blood, pharmacokinetics, therapeutic use)
- Tramadol
(adverse effects, blood, pharmacokinetics, therapeutic use)
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