Abstract | AIMS: To examine the expression of Epstein-Barr virus (EBV) transcripts encoding proteins homologous to important human proteins in diverse EBV associated diseases. The proteins were: BHRF1 (homologous to Bcl-2), BDLF2 (homologous to cyclin B1), BARF1 (homologous to intercellular cell adhesion molecule 1 (ICAM-1)), and BCRF1 (viral IL-10 (vIL-10), homologous to human IL-10 (hIL-10)). METHODS: RESULTS: CONCLUSIONS: vIL-10 and BDLF2 transcripts are expressed during productive EBV infection and are unlikely to be important in the pathogenesis of EBV associated malignancies. BARF1 appears to be expressed preferentially during viral latency and is more closely associated with malignant rather than benign epithelial proliferations. The alternative transcripts derived from the BHRF1 open reading frame may have very different roles during latent or productive infection.
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Authors | D P Hayes, A A Brink, M B Vervoort, J M Middeldorp, C J Meijer, A J van den Brule |
Journal | Molecular pathology : MP
(Mol Pathol)
Vol. 52
Issue 2
Pg. 97-103
(Apr 1999)
ISSN: 1366-8714 [Print] England |
PMID | 10474689
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Membrane Glycoproteins
- Viral Proteins
- Interleukin-10
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Topics |
- Epstein-Barr Virus Infections
(genetics)
- Gene Expression
- Herpesvirus 4, Human
(genetics)
- Humans
- Interleukin-10
(genetics)
- Leukoplakia, Hairy
(virology)
- Lymphoma
(virology)
- Membrane Glycoproteins
(genetics)
- Nasopharyngeal Neoplasms
(virology)
- Neoplasms
(virology)
- Reverse Transcriptase Polymerase Chain Reaction
- Sequence Homology, Amino Acid
- Transcription, Genetic
- Tumor Cells, Cultured
- Viral Proteins
(genetics)
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