Regional cerebral glucose metabolism and blood flow in a patient with Marchiafava-Bignami disease.

Abstract

We report functional neuroimaging studies of a 54-year-old man with Marchiafava-Bignami disease (MBD). Glucose metabolic images obtained by [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography showed diffusely reduced whole brain metabolism and strongly decreased metabolism in the frontal and parietal lobes, orbital gyrus, and thalamus. Cerebral perfusion images showed a similarly decreased radioactivity pattern as the metabolic images. Functional neuroimages would be useful for understanding the pathophysiologic processes of MBD.

• Authors: K Ishii, Y Ikerjiri, M Sasaki, H Kitagaki, E Mori
• Journal: AJNR. American journal of neuroradiology (AJNR Am J Neuroradiol) Vol. 20 Issue 7 Pg. 1249-51 (Aug 1999) ISSN: 0195-6108 [Print] United States
• PMID: 10472981 (Publication Type: Case Reports, Journal Article)

Chemical References

• Radiopharmaceuticals
• Fluorodeoxyglucose F18
• Iofetamine
• Glucose

Topics

• Alcohol-Related Disorders (diagnostic imaging, physiopathology)
• Brain (diagnostic imaging, metabolism)
• Brain Diseases (diagnostic imaging, etiology, physiopathology)
• Cerebrovascular Circulation
• Fluorodeoxyglucose F18
• Glucose (metabolism)
• Humans
• Iofetamine
• Male
• Middle Aged
• Radiopharmaceuticals
• Tomography, Emission-Computed
• Tomography, Emission-Computed, Single-Photon