Targeting nitric oxide to cancer cells: cytotoxicity studies of glyco-S-nitrosothiols.

Abstract

Glyco-S-nitrosothiols, fructose-2-SNAP and glucose-2-SNAP, were synthesized and found to be much more cytotoxic than SNAP in killing DU-145 human prostate cancer cells in vitro.

• Authors: Y Hou, J Wang, P R Andreana, G Cantauria, S Tarasia, L Sharp, P G Braunschweiger, P G Wang
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 9 Issue 15 Pg. 2255-8 (Aug 02 1999) ISSN: 0960-894X [Print] England
• PMID: 10465556 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents
• Nitric Oxide Donors
• Nitroso Compounds
• S-nitro-N-acetylpenicillamine
• fructose-2-SNAP
• glucose-2-SNAP
• Fructose
• Nitric Oxide
• Penicillamine
• Glucose

Topics

• Antineoplastic Agents (chemical synthesis, pharmacology)
• Drug Screening Assays, Antitumor
• Fructose (analogs & derivatives, chemical synthesis, pharmacology)
• Glucose (analogs & derivatives, chemical synthesis, pharmacology)
• Humans
• Male
• Nitric Oxide (metabolism)
• Nitric Oxide Donors (pharmacology)
• Nitroso Compounds (chemical synthesis, pharmacology)
• Penicillamine (analogs & derivatives, pharmacology)
• Prostatic Neoplasms (pathology)
• Tumor Cells, Cultured