Effects of Dai-kenchu-to on intestinal obstruction following laparotomy.

Abstract

To confirm the usefulness of Dai-kenchu-to for intestinal obstruction, investigation of the effects of Dai-kenchu-to on postoperative intestinal adhesion was conducted. Repeated administrations of Dai-kenchu-to (100 or 300 mg/kg) significantly inhibited the formation of intestinal obstruction. Motor disturbance and inflammation are thought to be involved in the etiology of intestinal adhesion. A single treatment of Dai-kenchu-to (300 mg/kg) significantly reduce intestinal transit time in postoperative ileus and chemically induced ileus. Dai-kenchu-to (10(-4) g/ml) significantly inhibited COX-2 activity. These results suggest that Dai-kenchu-to prevents postoperative intestinal adhesion by gastroprokinetic and anti inflammatic effects. Dai-kenchu-to thus demonstrates positive effect on postoperative ileus.

• Authors: T Hayakawa, Y Kase, K Saito, K Hashimoto, A Ishige, Y Komatsu, H Sasaki
• Journal: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi (J Smooth Muscle Res) Vol. 35 Issue 2 Pg. 47-54 (Apr 1999) ISSN: 0916-8737 [Print] Japan
• PMID: 10463435 (Publication Type: Journal Article)

Chemical References

• Drugs, Chinese Herbal
• Pharmaceutical Preparations
• Plant Extracts
• dai-kenchu-to
• Talc
• Prostaglandin-Endoperoxide Synthases

Topics

• Animals
• Disease Models, Animal
• Drugs, Chinese Herbal (pharmacology)
• Ileum (drug effects)
• Intestinal Obstruction (etiology, prevention & control)
• Male
• Mice
• Mice, Inbred ICR
• Panax
• Pharmaceutical Preparations
• Plant Extracts (pharmacology)
• Postoperative Complications (prevention & control)
• Prostaglandin-Endoperoxide Synthases (drug effects)
• Rats
• Rats, Sprague-Dawley
• Talc (adverse effects)
• Tissue Adhesions (etiology, prevention & control)
• Zanthoxylum
• Zingiberaceae