Possible mechanism of action of vanadium ions as an antidiabetic agent.

Abstract	Vanadium compounds, at much higher concentrations than they are typically ingested, are being considered for use in the treatment of diabetes mellitus. They exert an insulin-mimetic effect in an insulin-receptor-independent manner. In our study we obtained new data about the vanadium insulin-receptor-independent mechanism of action on cell membranes. When rat stomach smooth muscle samples are treated with NH4VO3 (10(-7) divided by 10(-5) this action is possibly exhibited with increased influx of Ca2+ through VDCa2+C.
Authors	K Terziyski, R Tzenova, E Milieva, S Vladeva
Journal	Folia medica (Folia Med (Plovdiv)) Vol. 41 Issue 1 Pg. 34-7 ( 1999) ISSN: 0204-8043 [Print] Bulgaria
PMID	10462917 (Publication Type: Journal Article)
Chemical References	Vanadium Receptor, Insulin Calcium
Topics	Animals Calcium (metabolism) Cell Membrane (drug effects, metabolism) Diabetes Mellitus (drug therapy) Muscle, Smooth (drug effects, metabolism) Rats Receptor, Insulin (metabolism) Signal Transduction Vanadium (pharmacology, therapeutic use)

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