[Use of leukinferon for prophylaxis of pyogenic complications in victims with thoracic wounds].

Abstract

The results of treatment of 131 victims with penetrating wounds of the thorax complicated by profuse bleeding, are presented. 36 of them after surgery to prevent pyogenous complications received 5 injections of leukinferon (test group); 95 patients who were not treated by leukinferon made up control group comparable with the test group by sex, age and character of wounds. Comparative analysis of the results showed that treatment with leukinferon has resulted in decrease of postoperative complications. In the test group the number of complications made up 47.2%, in control group--61%. Al the same time in the former group there was only one pyogenous complication (2.9%), while in control group--10 (10.6%). After the course of leukinferon leucocytic formula of the blood has become normal, the number of patients with immunodeficiency and imbalance of proteins markers of the acuteness of inflammatory process has decreased.

• Authors: G V Bulava, M M Abakumov, O A Druzenko, O A Markova, A N Pogodina, V B Khvatov
• Journal: Khirurgiia (Khirurgiia (Mosk)) Issue 7 Pg. 35-9 ( 1999) ISSN: 0023-1207 [Print] Russia (Federation)
• Vernacular Title: Primenenie leĭkinferona dlia profilaktiki gnoĭnykh oslozhneniĭ u postradavshikh s raneniiami grudi.
• PMID: 10459185 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Adjuvants, Immunologic
• Cytokines
• Drug Combinations
• Interferon Type I
• leukinferon

Topics

• Adjuvants, Immunologic (administration & dosage, therapeutic use)
• Adolescent
• Adult
• Aged
• Cytokines (administration & dosage, therapeutic use)
• Drug Combinations
• Female
• Follow-Up Studies
• Hemorrhage (etiology, surgery)
• Humans
• Injections, Intramuscular
• Interferon Type I (administration & dosage, therapeutic use)
• Male
• Middle Aged
• Surgical Wound Infection (prevention & control)
• Thoracic Diseases (etiology, surgery)
• Thoracic Injuries (complications, surgery)
• Thoracic Surgical Procedures
• Treatment Outcome
• Wounds, Penetrating (complications, surgery)