HLA-DRB1*0403 is associated with dominant protection against IDDM in the general Dutch population and subjects with high-risk DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype.

Abstract

Insulin-dependent (Type 1) diabetes mellitus (IDDM) is a genetically controlled T-cell mediated autoimmune disease. Recently, subtyping of HLA-DRB1*04 identified the HLA-DRB1*0403 allele to be associated with protection in Caucasoids with the highest risk heterozygous genotype DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201. Some studies confirmed this finding, but other reports were not consistent with a dominantly protective trait. We here report the frequency of HLA-DRB1*0403 in a large cohort (n=200) of Dutch patients with IDDM, their first-degree family members (n=370), and random controls (n=420) of the general population in The Netherlands. We found that HLA-DRB1*0403 is strongly associated with dominant protection against development of IDDM in unrelated subject, even in the context of the highest risk HLA-DQ phenotypes and HLA-DR4-DQB1*0302 (P < 0.0001).

• Authors: B O Roep, R Schipper, W Verduyn, G J Bruining, G M Schreuder, R R de Vries
• Journal: Tissue antigens (Tissue Antigens) Vol. 54 Issue 1 Pg. 88-90 (Jul 1999) ISSN: 0001-2815 [Print] England
• PMID: 10458327 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-DQ Antigens
• HLA-DQ alpha-Chains
• HLA-DQ beta-Chains
• HLA-DQA1 antigen
• HLA-DQB1 antigen
• HLA-DR Antigens
• HLA-DRB1 Chains

Topics

• Alleles
• Denmark (epidemiology)
• Diabetes Mellitus, Type 1 (epidemiology, genetics)
• HLA-DQ Antigens (genetics)
• HLA-DQ alpha-Chains
• HLA-DQ beta-Chains
• HLA-DR Antigens (genetics)
• HLA-DRB1 Chains
• Humans
• Risk Factors