Abstract | AIMS AND METHODS: To evaluate if the effects of long-term treatment with different antihypertensive drugs on left ventricular (LV) hypertrophy seen in meta-analysis could also be found in a cross-sectional study of elderly men, we investigated 584 70-year-old men with echocardiography of which 179 were treated for hypertension. RESULTS: Men on antihypertensive treatment showed a significantly higher LV mass than normotensive men (143 +/- 29 vs 132 +/- 28 g/m2, P < 0.01), but no significant difference in LV mass was seen between men on one antihypertensive drug (n = 129) and those on two drugs (n = 47). Among the men on monotherapy, no differences in LV mass between the subjects who were treated with calcium-antagonists (142 +/- 27 g/m2, n = 37), beta-blockers (140 +/- 29 g/m2, n = 66) or ACE-inhibitors (142 +/- 33 g/m2, n = 20) were found. Neither did blood pressure differ between these groups. Excluding subjects with coronary heart disease did not alter the results. Thiazides as monotherapy was uncommon in this population (n = 4) and therefore not evaluated. CONCLUSION:
|
Authors | B Andrén, L Lind, H Lithell |
Journal | Journal of human hypertension
(J Hum Hypertens)
Vol. 13
Issue 8
Pg. 499-504
(Aug 1999)
ISSN: 0950-9240 [Print] England |
PMID | 10455469
(Publication Type: Journal Article)
|
Chemical References |
- Adrenergic beta-Antagonists
- Angiotensin-Converting Enzyme Inhibitors
- Antihypertensive Agents
- Calcium Channel Blockers
|
Topics |
- Adrenergic beta-Antagonists
(therapeutic use)
- Aged
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Antihypertensive Agents
(therapeutic use)
- Blood Pressure
(drug effects, physiology)
- Calcium Channel Blockers
(therapeutic use)
- Cross-Sectional Studies
- Drug Therapy, Combination
- Echocardiography
- Humans
- Hypertension
(drug therapy, physiopathology)
- Hypertrophy, Left Ventricular
(prevention & control)
- Male
- Reference Values
|