Molecular remission in adult T cell leukemia after autologous CD34+ peripheral blood stem cell transplantation.

Abstract

This report describes a patient with acute-type adult T cell leukemia/lymphoma (ATLL) successfully treated by autologous CD34+ peripheral blood stem cell transplantation after fractionated total body irradiation and high-dose cytarabine and cyclophosphamide. A newly established inverse polymerase chain reaction method was used to demonstrate the disappearance of ATLL clonal cells. The patient achieved a sustained molecular remission after transplantation, but died from opportunistic infection 4 months after transplantation. Thus, autologous CD34+ peripheral blood stem cell transplantation is promising for this type of malignancy. However, a prudent clinical attitude toward immunological fragility after transplantation is needed for better outcome.

• Authors: M Nakane, K Ohashi, Y Sato, A Moriya, T Inoue, S Mori, S Tanikawa, H Akiyama, Y Maeda, T Sasaki, K Karasawa, Y Okuyama, K Hiruma, H Sakamaki
• Journal: Bone marrow transplantation (Bone Marrow Transplant) Vol. 24 Issue 2 Pg. 219-21 (Jul 1999) ISSN: 0268-3369 [Print] England
• PMID: 10455355 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antigens, CD34

Topics

• Antigens, CD34
• Female
• Hematopoietic Stem Cell Transplantation
• Humans
• Leukemia, T-Cell (genetics, pathology, therapy)
• Middle Aged
• Neoplastic Stem Cells
• Polymerase Chain Reaction
• Remission Induction
• Transplantation, Autologous