Abstract | PURPOSE: METHODS: RESULTS: After 30 min inhalation of CPT liposome aerosol, drug was deposited in the lungs (310 ng/g) and was followed promptly by the appearance of high concentrations in the liver (192 ng/g) and with lesser amounts appearing in other organs. Drug concentration in the brain was 61 ng/g. After intramuscular injection of CPT dissolved in DMSO, drug was released from the site of injection very slowly and accumulated mainly in the liver (136 ng/g). Only trace amounts appeared in the lungs (2-4 ng/g). These results demonstrate a prompt pulmonary and later systemic distribution of CPT following liposome aerosol administration. CONCLUSIONS: The substantial concentrations of CPT in lungs and other organs following inhalation of liposome aerosol suggest the possible benefit of it and of its more active derivative, 9-NC, in the treatment of lung, liver, kidney and brain cancer in humans.
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Authors | N V Koshkina, B E Gilbert, J C Waldrep, A Seryshev, V Knight |
Journal | Cancer chemotherapy and pharmacology
(Cancer Chemother Pharmacol)
Vol. 44
Issue 3
Pg. 187-92
( 1999)
ISSN: 0344-5704 [Print] Germany |
PMID | 10453719
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aerosols
- Antineoplastic Agents, Phytogenic
- Drug Carriers
- Liposomes
- Phosphatidylcholines
- 1,2-dilauroylphosphatidylcholine
- Camptothecin
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Topics |
- Aerosols
- Animals
- Antineoplastic Agents, Phytogenic
(administration & dosage, pharmacokinetics)
- Camptothecin
(administration & dosage, pharmacokinetics)
- Drug Carriers
- Female
- Humans
- Injections, Intramuscular
- Liposomes
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Nude
- Phosphatidylcholines
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