Studies on hepatic oxidative stress and antioxidant defence systems during arteether treatment of Plasmodium yoelii nigeriensis infected mice.

Abstract

Reactive Oxygen species play an important role in pathology during malaria infection. The status of hepatic oxidative stress and antioxidant defence indices was studied during Plasmodium yoelii nigeriensis (P. y. nigeriensis) infection in mice and arteether treatment of P. y. nigeriensis infected mice. P. y. nigeriensis infection caused a significant increase in hepatic xanthine oxidase, rate of lipid peroxidation, reduced glutathione (GSH) and glutathione reductase with progressive rise in parasitemia. This was accompanied by a significant decrease in hepatic superoxide dismutase (SOD) and catalase with increase in parasitemia. Arteether treatment (10 mg/kg body weight of mice) of infected mice from day 2 of post infection resulted in complete clearance of parasitemia on day 4 of post infection which was accompanied by restoration of all the oxidative stress and antioxidant defence indices to normal levels.

• Authors: N J Siddiqi, V C Pandey
• Journal: Molecular and cellular biochemistry (Mol Cell Biochem) Vol. 196 Issue 1-2 Pg. 169-73 (Jun 1999) ISSN: 0300-8177 [Print] Netherlands
• PMID: 10448917 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antimalarials
• Antioxidants
• Artemisinins
• Sesquiterpenes
• Xanthine Oxidase
• artemotil

Topics

• Animals
• Antimalarials (therapeutic use)
• Antioxidants (metabolism)
• Artemisinins
• Liver (metabolism, parasitology)
• Malaria (drug therapy, metabolism)
• Mice
• Oxidative Stress
• Plasmodium yoelii
• Sesquiterpenes (therapeutic use)
• Xanthine Oxidase (metabolism)