Treatment of neuroleptic-induced akathisia with the 5-HT2 antagonist mianserin. Double-blind, placebo-controlled study.

Abstract

BACKGROUND:

Serotonin (5-HT):dopamine imbalance may underlie neuroleptic-induced akathisia.

AIM:

To evaluate the efficacy of the 5-HT2 antagonist, mianserin in neuroleptic-induced akathisia.

METHODS:

Thirty neuroleptic-treated patients with schizophrenia were randomly allocated in a double-blind design to receive either mianserin (15 mg/day) or placebo for five days. Patients were assessed at baseline and on Days 3 and 5 by the Barnes Akathisia Scale (BARS), as well as by other relevant clinical rating scales.

RESULTS:

Compared with the placebo group, the mianserin-treated patients showed a significant reduction in all four BARS subscales by Day 5, with mean reductions in the BARS global score of 9.9% and 52.2%, respectively (P = 0.006). Response to treatment (a reduction of at least two points on the BARS global subscale), was noted in six patients (40%) in the mianserin group and only one patient (9.1%) in the placebo group (P = 0.04, log odds ratio 2.23).

CONCLUSIONS:

Mianserin at a low dose may be a promising therapeutic option for patients with acute neuroleptic-induced akathisia.

• Authors: M Poyurovsky, M Shardorodsky, C Fuchs, M Schneidman, A Weizman
• Journal: The British journal of psychiatry : the journal of mental science (Br J Psychiatry) Vol. 174 Pg. 238-42 (Mar 1999) ISSN: 0007-1250 [Print] England
• PMID: 10448449 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Serotonin Antagonists
• Mianserin

Topics

• Adult
• Akathisia, Drug-Induced (drug therapy, etiology)
• Double-Blind Method
• Female
• Humans
• Male
• Mianserin (therapeutic use)
• Schizophrenia (drug therapy)
• Serotonin Antagonists (therapeutic use)
• Treatment Outcome