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Influence of immunopotentiators on the antiporin immunoglobulin G subclass: distribution and protective immunity against murine salmonellosis.

Abstract
To improve the immune potential of porin (a pore-forming protein of Salmonella sp.), different immunopotentiators such as Freund's complete adjuvant (FCA), lipopolysaccharide (LPS) and polyoxydonium (PO) were evaluated by studying the nature of the protective immune response induced against murine Salmonellosis. The nontoxic, synthetic heteropolymer polyoxydonium was as good as LPS at inducing antiporin immunoglobulin G (IgG) antibodies and protective immunity. Analysis of the antiporin IgG subclass pattern revealed a preferential increase in a particular subclass based on the immunopotentiator used. Porin, alone or emulsified in FCA, elicited predominantly antiporin IgG1 antibodies, whereas LPS preferentially evoked antiporin IgG2a, IgG2b and IgG3 antibodies. Polyoxydonium induced a clear shift towards antiporin IgG2b antibodies. The significance of these antiporin IgG subclass antibodies in protection against murine Salmonellosis was studied by passive immunization and by analysing the infected mouse sera.
AuthorsK S Nandakumar, V R Muthukkaruppan
JournalScandinavian journal of immunology (Scand J Immunol) Vol. 50 Issue 2 Pg. 188-94 (Aug 1999) ISSN: 0300-9475 [Print] England
PMID10447924 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adjuvants, Immunologic
  • Antibodies, Bacterial
  • Immunoglobulin G
  • Immunoglobulin M
  • Lipopolysaccharides
  • Organic Chemicals
  • Porins
  • polyoxydonium
  • Freund's Adjuvant
Topics
  • Adjuvants, Immunologic
  • Animals
  • Antibodies, Bacterial (classification, immunology)
  • Disease Models, Animal
  • Female
  • Freund's Adjuvant (immunology)
  • Hypersensitivity, Delayed
  • Immunization, Passive
  • Immunoglobulin G (classification, immunology)
  • Immunoglobulin M (immunology)
  • Lipopolysaccharides (immunology)
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Organic Chemicals
  • Porins (immunology)
  • Salmonella Infections (immunology, prevention & control)
  • Salmonella typhimurium (immunology)

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