Identification of a gene encoding a human oxysterol-binding protein-homologue: a potential general molecular marker for blood dissemination of solid tumors.

Abstract	This study describes a new potential role in human cancer for a gene, HLM, isolated by differential display, that bears homology to an oxysterol-binding protein. A significant association between increased expression of HLM with metastatic disease was found. HLM mRNA levels were increased in circulating tumor cells in patients' peripheral blood and in primary human epithelial cells expressing the human papillomavirus16 E6 and E7 proteins. HLM mRNA was not detected in most normal human tissues, including peripheral blood and lymph node. These findings indicate that HLM may function as a potential marker for tumor dissemination.
Authors	M V Fournier, F Guimarães da Costa, M E Paschoal, L V Ronco, M G Carvalho, A B Pardee, F C Giumaraes
Journal	Cancer research (Cancer Res) Vol. 59 Issue 15 Pg. 3748-53 (Aug 01 1999) ISSN: 0008-5472 [Print] United States
PMID	10446991 (Publication Type: Comparative Study, Journal Article)
Chemical References	Biomarkers, Tumor E6 protein, Human papillomavirus type 16 Oncogene Proteins, Viral Papillomavirus E7 Proteins RNA, Messenger RNA, Neoplasm Receptors, Steroid Repressor Proteins oncogene protein E7, Human papillomavirus type 16 oxysterol binding protein
Topics	Amino Acid Sequence Biomarkers, Tumor (blood, genetics) Breast (cytology, metabolism) Breast Neoplasms (chemistry) Cell Line, Transformed Cells, Cultured Colonic Neoplasms (genetics, metabolism, pathology) Disease Progression Epithelial Cells (metabolism) Gene Expression Regulation, Neoplastic Genes HeLa Cells Humans Lung Neoplasms (blood) Molecular Sequence Data Neoplasm Metastasis Neoplastic Cells, Circulating Oncogene Proteins, Viral (physiology) Papillomaviridae (genetics) Papillomavirus E7 Proteins RNA, Messenger (biosynthesis) RNA, Neoplasm (biosynthesis) Receptors, Steroid (blood, genetics) Repressor Proteins Reverse Transcriptase Polymerase Chain Reaction Sequence Alignment Sequence Homology, Amino Acid

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