Abstract | OBJECTIVE: To test predictions based on data from immunogenetic and peptide-binding studies of collagen-induced arthritis in mice, in which it has been suggested that susceptibility to rheumatoid arthritis (RA) might be determined by the interaction between susceptibility alleles at the HLA-DQ locus and protective alleles at the HLA-DRB1 locus (including susceptibility effects for HLA-DQ7 and DQ8). METHODS: Predictions based on these models were tested in 166 healthy controls and 167 patients with RA, all of whom were typed for HLA-DRB1 and HLA-DQ alleles. RESULTS: In this population, HLA-DQ7 did not encode an increased risk for RA. This lack of susceptibility effect of HLA-DQ7 could not be attributed to competing HLA-DQ susceptibility alleles, protective HLA-DRB1 alleles, or the absence of DQA1*0301. CONCLUSION: These observations do not support the DR/DQ hypothesis in its present form.
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Authors | N de Vries, C van Elderen, H Tijssen, P L van Riel, L B van de Putte |
Journal | Arthritis and rheumatism
(Arthritis Rheum)
Vol. 42
Issue 8
Pg. 1621-7
(Aug 1999)
ISSN: 0004-3591 [Print] United States |
PMID | 10446860
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DQA1 antigen
- HLA-DR Antigens
- HLA-DRB1 Chains
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Topics |
- Alleles
- Arthritis, Rheumatoid
(genetics, immunology)
- Genetic Predisposition to Disease
- HLA-DQ Antigens
(genetics)
- HLA-DQ alpha-Chains
- HLA-DR Antigens
(genetics)
- HLA-DRB1 Chains
- Humans
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