The effects of testosterone on the mice pinealocytes: a quantitative study.

In order to determine the effects of testosterone upon the function of the pineal gland we quantitated, under the electron microscope, the number of dense-core vesicles, lysosomes, lipid droplets and the fractional volume of the pineal gland components in adult male mice. We studied six groups of mice submitted to different treatments as follows: treated with testosterone propionate (0.1 mg/10 g body weight for 15 consecutive days), castrated and the respective control mice. In mice treated with testosterone we observed a decrease in the number and fractional volume of dense-core vesicles and an increase in the fractional volume of lysosomes and lipid droplets. In castrated mice, without treatment, we observed a decrease in the number of lysosomes and an increase in the number and fractional volume of dense-core vesicles. These results show that testosterone is closely related to the secretory process of mice pinealocytes, playing an inhibitory role upon the functional activity of the pineal gland.
AuthorsC A Redins, J C Novaes, K B Torres
JournalTissue & cell (Tissue Cell) Vol. 31 Issue 2 Pg. 233-9 (Apr 1999) ISSN: 0040-8166 [Print] SCOTLAND
PMID10445300 (Publication Type: Journal Article)
Chemical References
  • Testosterone
  • Animals
  • Male
  • Mice
  • Pineal Gland (cytology, drug effects, ultrastructure)
  • Testosterone (pharmacology, physiology)

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