Effects of saiboku-to on dual-phase bronchoconstriction in asthmatic guinea pigs.

Abstract

In recent years, bronchial asthma has come to be regarded pathologically as a chronic inflammatory disease of the respiratory tract. Inhalational steroids and antiinflammatory drugs are recognized as being effective against bronchial asthma. In this study, the effects of Saiboku-to, a Chinese herbal (Kampo) formulation, were investigated on asthmatic guinea pigs sensitized to ovalbumin (OA). Following 7-day administration of Saiboku-to (500 micrograms/kg), the late asthmatic response (LAR) to an antigen challenge was found to be inhibited. The number of eosinophils in fluid obtained by bronchoalveolar lavage (BAL) 4 h after antigen challenge was decreased while the infiltration of eosinophils and T-lymphocytes into the lung parenchyma was inhibited. These findings suggest that Saiboku-to has the potential to become a useful drug in the treatment of bronchial asthma.

• Authors: Y Tohda, R Haraguchi, H Kubo, M Muraki, M Fukuoka, S Nakajima
• Journal: Methods and findings in experimental and clinical pharmacology (Methods Find Exp Clin Pharmacol) 1999 Jul-Aug Vol. 21 Issue 6 Pg. 449-52 ISSN: 0379-0355 [Print] Spain
• PMID: 10445239 (Publication Type: Journal Article)

Chemical References

• Antigens
• Bronchodilator Agents
• Drugs, Chinese Herbal
• Ovalbumin

Topics

• Animals
• Antigens (administration & dosage)
• Asthma (drug therapy, immunology, pathology, physiopathology)
• Bronchoconstriction (drug effects, immunology)
• Bronchodilator Agents (pharmacology)
• Disease Models, Animal
• Drugs, Chinese Herbal (pharmacology)
• Guinea Pigs
• Male
• Medicine, Chinese Traditional
• Ovalbumin (administration & dosage)