Sensitization to triglycidylisocyanurate (TGIC) with cutaneous and respiratory manifestations.

Abstract

The case is presented of a man with allergic contact dermatitis and occupational asthma due to triglycidylisocyanurate (TGIC), which is used as a hardener in thermosetting powder paint. The contact dermatitis was confirmed by patch testing (TGIC 0.5% and 5% in petrolatum), and the occupational asthma was confirmed by bronchial provocation testing: two challenges to an aerosol of lactose containing TGIC (0.05% and 0.1%, w/w, each for 0.5+1+2+4 min) led to a maximal decrease in FEV1 of 22% and 31% after 6 and 4 h, respectively. Skin prick tests with unconjugated TGIC were possibly positive. This case confirms that exposure to TGIC in powder paints may cause not only contact dermatitis, but also occupational asthma.

• Authors: L Meuleman, A Goossens, C Linders, F Rochette, B Nemery
• Journal: Allergy (Allergy) Vol. 54 Issue 7 Pg. 752-6 (Jul 1999) ISSN: 0105-4538 [Print] Denmark
• PMID: 10442533 (Publication Type: Case Reports, Journal Article)

Chemical References

• Triazines
• teroxirone

Topics

• Adult
• Asthma (chemically induced)
• Bronchial Provocation Tests
• Dermatitis, Allergic Contact (etiology)
• Dermatitis, Occupational (etiology)
• Forced Expiratory Volume
• Humans
• Male
• Occupational Diseases (chemically induced)
• Occupational Exposure
• Patch Tests
• Triazines (adverse effects)