Abstract |
We recently reported that feeding cyanidin 3-O-beta-d-glucoside (C3G), a typical anthocyanin pigment, lowered the serum thiobarbituric acid-reactive substance ( TBARS) concentration and increased the oxidation resistance of the serum to lipid peroxidation in rats. These results suggest that C3G acts as a potent antioxidant in vivo when acute oxidative stress is encountered. In the present study, we evaluated whether feeding C3G suppresses oxidative injury to the liver caused by hepatic ischemia-reperfusion (I/R), which was used as a model for oxidative stress. Rats were fed a diet containing C3G (2 g/kg diet) for 14 days and then subjected to hepatic I/R. I/R treatment elevated the liver TBARS concentration and the serum activities of marker enzymes ( glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, and lactate dehydrogenase) for liver injury and lowered the liver reduced glutathione concentration. Feeding C3G significantly suppressed these changes caused by hepatic I/R. Although the liver ascorbic acid concentration was also lowered by hepatic I/R, feeding C3G restored this concentration more quickly compared to the control rats. These results indicate that orally administered C3G suppresses I/R-induced oxidative damage and suggest that C3G functions as a potent antioxidant in vivo under oxidative stress.
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Authors | T Tsuda, F Horio, J Kitoh, T Osawa |
Journal | Archives of biochemistry and biophysics
(Arch Biochem Biophys)
Vol. 368
Issue 2
Pg. 361-6
(Aug 15 1999)
ISSN: 0003-9861 [Print] United States |
PMID | 10441388
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 1999 Academic Press. |
Chemical References |
- Anthocyanins
- Antioxidants
- Glucosides
- cyanidin-3-O-beta-glucopyranoside
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Topics |
- Animals
- Anthocyanins
(administration & dosage)
- Antioxidants
(administration & dosage)
- Glucosides
(administration & dosage)
- Ischemia
(prevention & control)
- Lipid Peroxidation
(drug effects)
- Liver
(blood supply, physiopathology)
- Male
- Rats
- Rats, Wistar
- Reperfusion Injury
(prevention & control)
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