[A preliminary clinical observation of giant cell tumor of bone treated by adriamycin-loaded chitosan drug delivery system].

Abstract

In order to observe the curative effect and general reaction of locally used adriamycin (ADM)-loaded chitosan drug delivery system on giant cell tumor of bone after curettage. The cavities of 4 cases of giant cell tumor after curettage were filled with ADM-loaded chitosan drug delivery system with 4 times the dosage usually used for intravenous application. After operation, the concentration of ADM in plasma on the 1st, 2nd and 5th day, and the functions of liver and kidney on the 1st week, 1st month and 6th month were all investigated. The results were that the concentration of ADM in plasma was (143.05 +/- 27.55) ng/ml, (52.17 +/- 11.28) ng/ml and (4.25 +/- 3.07) ng/ml respectively, and the functions of liver and kidney were all normal in 6 months. After a follow-up of 7-19 months, no local or general reactions were observed and X-ray showed no recurrence. Therefore, it was concluded that the locally used ADM-loaded chitosan delivery system was safe and effective in treatment of giant cell tumor of bone after curettage.

• Authors: Y Zhang, C Hou, A Chen
• Journal: Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery (Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi) Vol. 12 Issue 5 Pg. 280-2 (Sep 1998) ISSN: 1002-1892 [Print] China
• PMID: 10437104 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Drug Carriers
• Chitin
• Doxorubicin
• Chitosan

Topics

• Adult
• Antineoplastic Agents (administration & dosage)
• Chitin (analogs & derivatives)
• Chitosan
• Doxorubicin (administration & dosage)
• Drug Carriers
• Drug Delivery Systems
• Female
• Femoral Neoplasms (drug therapy, surgery)
• Follow-Up Studies
• Giant Cell Tumor of Bone (drug therapy, surgery)
• Humans
• Male
• Postoperative Period