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Effect of body mass index and follicular synchrony in the ovarian response to ovulation induction with menotropins.

AbstractOBJECTIVE:
To determine the correlation between body mass index, follicular synchrony, and pregnancy rate in a controlled ovarian hyperstimulation program with menotropins.
SUBJECTS AND METHODS:
Seventy-nine hyperstimulation cycles were evaluated. Transvaginal ultrasonographic control was performed and 10,000 IU of human chorionic gonadotropin were administered when the dominant follicle reached a diameter > 16 mm. In order to evaluate the follicular response, the ovarian synchrony factor was used (# follicles > or =16 mm/# follicles > 10 mm). For the statistical analysis, linear correlation and chi-square tests were used.
RESULTS:
When patients had a normal body mass index there was a positive correlation ( r = .52) between body mass index (kg/m(1.5)) and the ovarian synchrony factor. Weight deficiency and obesity had a deleterious effect on the ovarian response ( r = -.47 and r = -.77, respectively). There was a significant difference in the number of pregnancies in patients with ideal weight in relationship to the subgroup with weight deficit.
CONCLUSIONS:
An adequate body constitution increases the possibilities of achieving success in ovulation induction programs; on the other hand, weight disturbances have a deleterious effect on ovulation.
AuthorsA Kably-Ambe, J Barrón-Vallejo, L M Limón-Luque
JournalInternational journal of fertility and women's medicine (Int J Fertil Womens Med) 1999 May-Jun Vol. 44 Issue 3 Pg. 156-9 ISSN: 1534-892X [Print] United States
PMID10435915 (Publication Type: Journal Article)
Chemical References
  • Fertility Agents, Female
  • Menotropins
Topics
  • Body Mass Index
  • Chi-Square Distribution
  • Female
  • Fertility Agents, Female (therapeutic use)
  • Follicular Phase (drug effects)
  • Humans
  • Infertility, Female (drug therapy, etiology)
  • Menotropins (therapeutic use)
  • Ovulation Induction (methods)
  • Pregnancy
  • Pregnancy Rate
  • Ultrasonography
  • Vagina (diagnostic imaging)

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