Abstract | RATIONALE: OBJECTIVE: This study examined the modulation of 3alpha, 5alpha THP-induced catalepsy by adenosinergic agents. METHODS:
Catalepsy induced by 3alpha, 5alpha THP (2-8 microg, ICV) was assessed by bar test periodically up to 3 h in mice. Adenosine A1, A2A or A3 receptor agonists or antagonists were given IP or ICV prior to 3alpha, 5alpha THP. Some animals received IP dopamine D2 receptor agonist or antagonist 30 min prior to above combination treatment. RESULTS: CONCLUSIONS:
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Authors | S N Mandhane, R T Khisti, C T Chopde |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 144
Issue 4
Pg. 398-404
(Jun 1999)
ISSN: 0033-3158 [Print] Germany |
PMID | 10435413
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dopamine Agonists
- Dopamine Antagonists
- GABA Modulators
- Purinergic P1 Receptor Agonists
- Purinergic P1 Receptor Antagonists
- Receptor, Adenosine A2A
- Receptor, Adenosine A3
- Pregnanolone
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Topics |
- Animals
- Catalepsy
(chemically induced, drug therapy)
- Dopamine Agonists
(pharmacology)
- Dopamine Antagonists
(pharmacology)
- GABA Modulators
- Male
- Mice
- Pregnanolone
- Purinergic P1 Receptor Agonists
- Purinergic P1 Receptor Antagonists
- Receptor, Adenosine A2A
- Receptor, Adenosine A3
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