[Extra-intestinal manifestations and complications in chronic active ulcerative colitis in childhood and adolescence].

A 18-year-old girl suffered from chronic active ulcerative colitis for ten years with growth retardation, primary amenorrhoea and osteopenia, so that total colectomy had been discussed as a possible treatment option. However, clinical remission was reached using a medication with budesonide (9 mg), mesalazine (3 g) and azathioprine (100 mg) when a painful ulcer occurred at the right lower leg.
The clinical examination revealed an ulcer of 7 cm diameter with a red-bluish margin at the right lower leg. The typical clinical features led to the diagnosis of pyoderma gangrenosum.
High doses of orally administered prednisolone induced the healing of the pyoderma gangrenosum within 2 months. After another 2 months systemic steroids were discontinued. Further laboratory tests confirmed secondary adrenal and ovarian failure (negative CRH-GnRH-test). Change of drug therapy to hydrocortisone (25 mg) in combination with mesalazine (3 g) and azathioprine (100 mg) improved the clinical course. Hydrocortisone was gradually reduced until CRH-GnRH-response returned to normal.
Drug therapy with azathioprine can be regarded as a treatment option in pediatric patients with chronic active inflammatory bowel disease. It can be concluded from this case report that faced with controversial therapeutic options in adolescent patients the decision mainly depends on the clinical experience of the physician than on the results of controlled clinical trials.
AuthorsD Hüppe, B Schenck, A Tromm
JournalDeutsche medizinische Wochenschrift (1946) (Dtsch Med Wochenschr) Vol. 124 Issue 27 Pg. 824-8 (Jul 9 1999) ISSN: 0012-0472 [Print] GERMANY
Vernacular TitleExtraintestinale Manifestationen und Komplikationen bei chronisch aktivem Verlauf der Colitis ulcerosa im Kindes- und Jugendalter.
PMID10432942 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Mesalamine
  • Budesonide
  • Prednisolone
  • Azathioprine
  • Hydrocortisone
  • Adolescent
  • Azathioprine (administration & dosage, adverse effects)
  • Budesonide (administration & dosage, adverse effects)
  • Child
  • Colitis, Ulcerative (complications, diagnosis, drug therapy)
  • Diagnosis, Differential
  • Drug Therapy, Combination
  • Female
  • Humans
  • Hydrocortisone (administration & dosage)
  • Leg Ulcer (complications, diagnosis, drug therapy)
  • Male
  • Mesalamine (administration & dosage, adverse effects)
  • Prednisolone (administration & dosage)
  • Pyoderma Gangrenosum (diagnosis, drug therapy, etiology)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: