Androstenediol (AED) prevents neuroendocrine-mediated suppression of the immune response to an influenza viral infection.

Abstract

The goal of these studies was to analyze the ability of androstenediol (AED) to counter-regulate the influences of stress on anti-viral immune responses. Male C57BL/6 mice, treated with 320 mg/kg AED were infected with influenza virus and subjected to repeated cycles of restraint (RST). AED blocked RST-mediated suppression of cell recruitment to the draining lymph node, lung NK cell activity, and CD4 + T cell activation. In addition, mice treated with AED had lower pre-corticosterone levels as compared to vehicle controls and the RST-mediated elevation of corticosterone was significantly blunted by AED treatment. These data suggest that AED functions to augment anti-viral immune responses by counter-regulating glucocorticoid function.

• Authors: D A Padgett, J F Sheridan
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 98 Issue 2 Pg. 121-9 (Aug 03 1999) ISSN: 0165-5728 [Print] Netherlands
• PMID: 10430045 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Anabolic Agents
• Interleukin-10
• Interferon-gamma
• Androstenediol
• Corticosterone

Topics

• Anabolic Agents (pharmacology)
• Androstenediol (pharmacology)
• Animals
• Corticosterone (blood)
• Cytotoxicity Tests, Immunologic
• Hypothalamo-Hypophyseal System (immunology, virology)
• Immune Tolerance
• Influenza A virus (immunology)
• Interferon-gamma (immunology, metabolism)
• Interleukin-10 (immunology, metabolism)
• Killer Cells, Natural (immunology, virology)
• Kinetics
• Leukocytes, Mononuclear (immunology, metabolism)
• Lymphatic Diseases (immunology, virology)
• Male
• Mice
• Mice, Inbred C57BL
• Neurosecretory Systems (drug effects, immunology, virology)
• Orthomyxoviridae Infections (immunology, mortality)
• Pituitary-Adrenal System (immunology, virology)
• Stress, Physiological (immunology)
• Survival Analysis