| Abstract | Although it is generally accepted that schistosomal granuloma formation results from a T-cell dependent host response towards the parasite egg, attention has recently been focused on the involvement of B-cells in the induction of schistosome-induced pathology. In this study we investigated the involvement of two functionally different B-cell populations in the formation of the Schistosoma mansoni granuloma: naive and antigen-stimulated B-cells. In liver granulomas two distinct B-cell populations were found, namely unstimulated B-cells at the periphery of the granuloma and antigen-stimulated, syndecan-1 positive B-cells in the inner part near the deposited egg. Intestinal granulomas differed by their relative lack of unstimulated B-cells at the granuloma periphery, but like hepatic granulomas intestinal granulomas also have syndecan-1 positive B-cells. From our results, we conclude that B-cells are important constituents of the S. mansoni granuloma. |
| Authors | W Jacobs, J Bogers, E Van Marck
(Affiliation: Department of Pathology, University of Antwerp (U.I.A.), Vlaanderen.)
|
| Journal | Acta gastro-enterologica Belgica
(Acta Gastroenterol Belg)
1999 Apr-Jun
Vol. 62
Issue 2
Pg. 178-81
ISSN: 0001-5644 BELGIUM |
| PMID | 10427778
(Publication Type: Journal Article)
|
| Chemical References |
- Antigens, CD40
- Membrane Glycoproteins
- Proteoglycans
- Sdc1 protein, mouse
- Syndecan-1
- Syndecans
|
| Topics |
- Animals
- Antigens, CD40
(analysis)
- B-Lymphocyte Subsets
(pathology)
- Granuloma
(parasitology, pathology)
- Liver Diseases, Parasitic
(pathology)
- Male
- Membrane Glycoproteins
(analysis)
- Mice
- Proteoglycans
(analysis)
- Schistosomiasis mansoni
(pathology)
- Syndecan-1
- Syndecans
|
