Clinical outcome in localized renal cell carcinomas related to immunoexpression of proliferating cell nuclear antigen, Ki-67 antigen, and tumor size.

Abstract

This study was designed to clarify the relationship between clinical outcome and immunoexpression of proliferating cell nuclear antigen (PCNA) and Ki-67 antigen (Ki-67) in 71 localized renal cell carcinomas (RCCs) of Robson stage I and II, related to the disease recurrence and tumor size. PCNA and Ki-67 expressions showed significant differences between non-recurring and recurring groups and more variability in stage II than in stage I. Recurrence rates according to tumor size were 0% for </=2.5 cm, 4% for 2.5 to 5.0 cm, and 55.8% for >/=5.0 cm. It was concluded that PCNA and Ki-67 expression profiles were considered to be closely related to tumor stage and showed some promise for predicting the disease recurrence.

• Authors: H Onda, M Yasuda, A Serizawa, R Y Osamura, N Kawamura
• Journal: Oncology reports (Oncol Rep) 1999 Sep-Oct Vol. 6 Issue 5 Pg. 1039-43 ISSN: 1021-335X [Print] Greece
• PMID: 10425300 (Publication Type: Journal Article)

Chemical References

• Ki-67 Antigen
• Proliferating Cell Nuclear Antigen

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Renal Cell (immunology, pathology, physiopathology)
• Cell Division
• Female
• Humans
• Ki-67 Antigen
• Kidney Neoplasms (immunology, pathology, physiopathology)
• Male
• Middle Aged
• Neoplasm Staging
• Prognosis
• Proliferating Cell Nuclear Antigen