Abstract |
KIN-806 is one of the newly developed 2-nitroimidazole derivative hypoxic cell radiosensitizers. The tumor growth control and the suppression of lung metastasis induced by KIN-806 were evaluated. Female C3H/He mice and SCCVII tumor cells were used. 30 Gy or 40 Gy was delivered as local irradiation. 0.2 g/kg or 0.4 g/kg KIN-806 was administered 30 min before this treatment to the KIN-806 administered groups. The enhancement ratio of KIN-806 evaluated using the growth delay method was 1.8. KIN-806 showed an excellent effect as a radiosensitizer. Furthermore, KIN-806 suppressed lung metastasis regardless of radiation, and the control of the metastatic lung nodules did not depend on the irradiation dose but rather on the KIN-806 dose (0.2 g/kg < 0.4 g/kg). KIN-806 is a promising bifunctional radiosensitizer which promotes anti- tumor activity in addition to having a radiosensitizing effect.
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Authors | T Inomata, Y Ogawa, S Itoh, S Kariya, N Hamada, A Nishioka, S Yoshida, H Nagasawa, H Hori, S Inayama |
Journal | International journal of molecular medicine
(Int J Mol Med)
Vol. 4
Issue 3
Pg. 257-60
(Sep 1999)
ISSN: 1107-3756 [Print] Greece |
PMID | 10425275
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- KIN 806
- Nitroimidazoles
- Radiation-Sensitizing Agents
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Topics |
- Animals
- Antineoplastic Agents
(chemistry, therapeutic use)
- Dose-Response Relationship, Drug
- Female
- Gamma Rays
- Lung Neoplasms
(drug therapy, pathology, secondary)
- Mice
- Mice, Inbred Strains
- Molecular Structure
- Nitroimidazoles
(administration & dosage, therapeutic use)
- Radiation-Sensitizing Agents
(therapeutic use)
- Tumor Cells, Cultured
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