Abstract |
The aim of this longitudinal study was to evaluate tubular proteinuria in rats with unilateral (UPO) and bilateral (BPO) partial ureteral obstruction with the dimercaptosuccinic acid ( DMSA) scan as the gold standard for measuring renal tubular damage. We studied 70 female Wistar rats: 28 animals with UPO, 28 animals with BPO, 7 sham-operated animals, and 7 controls. All animals with obstructed ureters showed renal dilatation on the diethylenetriaminepentaacetic acid DTPA images 1 and 5 weeks postoperatively. One week following UPO and BPO, tubular proteinuria and urinary N-acetyl-beta-D-glucosaminidase (NAG) activity increased (P < 0.01) and the absolute DMSA uptake decreased (P < 0.01). Persistently (week 6) high tubular proteinuria was found in 29% of the animals and was related to severe damage on the DMSA scan (P < 0.01) and to albuminuria (P < 0.05). Renal tubular damage was demonstrated by measuring renal enzymes, tubular proteins, and DMSA uptake after UPO and BPO. Persistent elevated tubular proteinuria was related to severely damaged kidneys.
|
Authors | K Everaert, C Van de Wiele, J Delanghe, H Vander Eecken, J P Van Haelst, J Van de Voorde, R A Dierckx, W Oosterlinck |
Journal | Urological research
(Urol Res)
Vol. 27
Issue 2
Pg. 127-33
(Apr 1999)
ISSN: 0300-5623 [Print] Germany |
PMID | 10424394
(Publication Type: Journal Article)
|
Chemical References |
- Proteins
- technetium Tc 99m tin dimercaptosuccinic acid
- technetium Tc 99m-Sn-DTPA
- Technetium Tc 99m Dimercaptosuccinic Acid
- Acetylglucosaminidase
- Technetium Tc 99m Pentetate
|
Topics |
- Acetylglucosaminidase
(urine)
- Animals
- Female
- Hydronephrosis
(diagnostic imaging, metabolism)
- Proteins
(analysis)
- Proteinuria
(metabolism, urine)
- Radionuclide Imaging
- Rats
- Rats, Wistar
- Technetium Tc 99m Dimercaptosuccinic Acid
(metabolism)
- Technetium Tc 99m Pentetate
(analogs & derivatives, metabolism)
- Time Factors
- Ureteral Obstruction
(diagnostic imaging, metabolism, urine)
|