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[A case of pharyngeal-cervical-brachial variant of Guillain-Barré syndrome with positive anti-galactocerebroside (Gal-C) IgM antibody].

Abstract
A 49-year-old man presented with hoarseness, dysphagia, muscle atrophy and weakness of deltoid, trapezius, sternocleidomastoid, rhomboid, anterior serratus, infraspinatus and supraspinatus. Anti-Gal-C IgM antibody was positive in the serum. The other antiganglioside antibodies (GM1, GM2, GM3, GD1a, GD1b, GD3, GT1a, GT1b, GQ1b, GA1, GalNAc-GD1a, GM1b) were negative. Patient contracted pneumonia but whether it was due to mycoplasma was not evident. Plasmapheresis improved his clinical state including a decrease of the antibody. This case was diagnosed pharyngeal-cervical-brachial variant of Guillain-Barré syndrome, and anti-Gal-C antibody seemed to be correlated with the pathogenesis of this syndrome. Gal-C is a major glycolipid of myelin and the cell membrane of the myelin-forming cell (oligodendrocytes and Schwann cells) and is free of specific localization and distribution. The mechanism how the anti-Gal-C IgM antibody induced bulbar paralysis and the symptoms localizing neck and upper limbs remains to be known.
AuthorsJ Kasuya, T Miyazono, S Takenaga, K Arimura, M Osame, S Kusunoki
JournalRinsho shinkeigaku = Clinical neurology (Rinsho Shinkeigaku) Vol. 39 Issue 5 Pg. 538-41 (May 1999) ISSN: 0009-918X [Print] Japan
PMID10424145 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Autoantibodies
  • Galactosylceramides
  • Immunoglobulin M
  • galactocerebroside
Topics
  • Autoantibodies (blood)
  • Galactosylceramides (immunology)
  • Humans
  • Immunoglobulin M (blood)
  • Male
  • Middle Aged
  • Plasmapheresis
  • Polyradiculoneuropathy (classification, immunology, therapy)

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